The next border of cell transplantation can be involved in the eyes. In today's research, scientists report that experimental therapy has helped people injured in their cornea.
The researchers that the eyes and ears are the leaders of the clinic experiment at the I/II of 14 patients. In most cases, the treatment – the crop sound from other healthy eyes – Epeared to restore the damaged corneal surface of the people safely tend to improve their vision as well. Research results may lead to a new treatment for an eye injury that does not respond to general options. Researchers said.
The cornea is a transparent face of the eyes that both protect and help us see clearly by focusing on light on the retina. When the cornea of people have a scar from serious injuries or medical infections, it is usually treated by moving a healthy corneal tissue from donors, also known as corneal transplantation.
But sometimes the injury is so spacious that the large but limited corneal cells of the limbal lining – sound cells filled the cells on the surface of the cornea. This depletion is called Limbal Lack of Limbal and causes people to have permanent corneal surfaces, which means that the general cornea may be latting (without the donated corneal sounds in the end).
“When people lack corneal cells, which are very serious conditions, they can have white cornea and without vision. And has a lot of pain and uncomfortable There is no good way to preserve that. “The leading researchers ULA Jurkunas Director cornea Service at Mass Eye and Ear told GizModo.
Many research teams have worked for many years to fix these difficult cases and Jurkunas and her team at Mass Eye and now believe that they are an important step in doing so. They have developed safely to gather techniques and then grow cells for health from the non -injured cornea of a person. These cells are called the limbal autolagous membrane cells that have been cultivated (Calec) are included with the grave of the cell tissue, which will be transpired to the injured cornea of the person.
Previous work of the team in four patients meet Calec cemetery is safe and effective at least in the short term. In new research Published Tuesday in Nature Communications The team collected data from 14 patients to 18 months after their steps.
Overall, 92% or the patient shows at least some of the calec in half later, with 77% experienced. (Three patients have received the second bribe with complete response.) All patients have at least their vision as well. And the transplant seems to be recognized that it is not able to report violent unwanted events that are linked to the process. (One person has been infected with bacteria many months later, although this is the result of using chronic contact lenses).
“Many of them have a good change in their symptoms. And these things are truly successful without current treatment. But now they can work, “Jurkunas said.” I have a patient told me, “I have actually returned.
This step is still experimenting or the course. It is possible that many patients responded to Calec's grave will still need to use additional cornea for their vision to improve significantly. But according to scientists, this is the first sound of the children's voice cells in the United States that will be used in people with blind cornea.
“I think this is a very large rock for cell voice therapy. Again, we do not use audio cells from embryo cells. These are sound cells obtained from adults that are already in our body. But we can control them and create products that we treat the body of the person with their own audio cells, “Jurkunas said.
The researchers are still trying to get a larger clinic experiment, which can be carried out at different eye centers, so the experimental procedures cannot be used with any patient at this time. They also hope to improve technology, such as being able to practice and transplant audio cells from other donors, which will open the treatment for two damaged cornea. If the team works continuously to show the CALEC contract and similar treatment, it may become a new standards for these single cases.