The Hong Kong-based company has agreed to sell most of its share in two key ports on the Panama Canal to a group led by the US investment company Blackrock.
The sale comes after weeks of complaining by President Donald Trump that the channel is under Chinese control and that the US should take control of the main shipping route.
Through the CK Hutchison Holding subsidiary operates ports at the Atlantic Ocean and the Pacific to the channel.
Tuesday said he would sell his interests as part of a $ 22.8 billion deal (£ 17.8 billion).
CK Hutchison, Founded by Hong – I'll be there for youIt is not owned by the Chinese government. But his base in Hong Kong means that it acts under Chinese financial laws. It has been running the ports since 1997.
The deal includes a total of 43 ports in 23 countries worldwide, including the two channel terminals. This will require approval from the Panam government.
The Panama channel of 51 miles (82 km) cuts into the nation in Central America and is the main link between the Atlantic and Pacific.
Up to 14,000 ships travel through it every year, including container ships carrying cars, natural gas and other goods, and warships.
It was built in the early 1900s. The United States maintained control over the channel area until 1977, when the contracts gradually gave way back to Panama.
After a period of joint control, Panama took control of the only control in 1999.
Trump has made several arguments for restoring control over the channel and the surrounding area. He claims that Chinese influence is a threat to national security that investment in the United States in the initial construction of the channel justifies to take back control and that US ships are being charged too much to use the water road.
On a visit to Panama in February, US Secretary of State Marco Rubio asked the country to make “immediate change” of what he calls China's “influence and control” over the channel.
Panama has rejected the demands of the US government, and President Jose Raul Mulino said the channel “is and will remain” in the hands of the Central American side.
In a statement that reported the business deal, Frank Sixth, a co-reigning director of CK Hutchison, said: “I would like to emphasize that the transaction is purely commercial in nature and completely unrelated to the latest political news related to Panama ports.”
Blackrock is one of the largest asset management companies in the world. The group that buys the ports also includes Terminal Investment Limited, a Swiss company.