Pillar cell It is part of our immune system protecting our bodies from viruses, bacteria and even harmful substances that are released from snakes and insect bites. When alerts the presence of the invaders, the hull pole can create mucus, stimulate swelling and itching and cause the muscles to shrink in the respiratory tract, our stomach and intestines. While these symptoms allow the body to destroy or expel larger invaders, the enlightenment cells cause allergic reactions, including the condition of life and the Council that will be trained.
If there is details in the file study Published on Monday to signal the journal and the therapy. The researchers have developed the compounds that blocked the pillars from Trigging, especially that difficult to practice and sometimes the reaction of life threats. These include colon symptoms (IBS), asthma, chronic itching and migraine. According to the fabric, it is considered a deceived reaction. These conditions have a recent leg. It is a type of allergy as specified by the researchers. The compound seems to reduce the symptoms dramatically and as a result, the risk of death is reduced.
“We therefore see that this is a very high substance,” Christa Müller, the co -authors of the study of chemical research of the membrane protein at Bonn University, said at a university. statement–
It is different from certain allergic reactions, which the immune cells called antibodies, warning the cells of the pillars for the appearance of the intruders that are difficult to the train. This causes reaction. “Of unique characteristics that are difficult to treat and remain to this day,” Müller explained.
15 years ago, Müller and colleagues identified the name MRGPRX2 in the membrane of the “open” pillar. Some molecules Attached to it. “Previously, this switch would have to be blocked,” Müller continued. “The question is: how?”
To solve this problem, the team has tested a compound that has a tendency from 40,000 collection. Previously, the Müller department “We used that light when opening MRGPRX2. Therefore, we can test whether the activity blog is effective or not.” Ghazl Al Hamwi, Müller's Ph.D., explained and with this method, the team discovered the molecule.
They use that molecule to develop substances that still work very low and prove the effectiveness of allergic reactions that threatens life in rats and blocks the MRGPRX2 in the separate human pole cells. They also claim that the molecules are just the intended receiver blocks, which avoid the risk of side effects.
While Al Hamwi, Müller and their colleagues have improved the efficiency and duration of the better substances, and the human experiments ultimately occur before being approved and trade as a drug. However, it has an impact that can save patients with inflammation and those who are at risk of shock.