Wegovy ate your heart. In new research reports, scientists say that they have discovered natural hormones, which may help people weigh while avoiding side effects related to semaglutide (active ingredients in Ozempic and Wegovy) and similar drugs.
The researchers team at Stanford Medicine conducted Published Last week in natural journals With the help of artificial intelligence, the team has identified an unknown Peptide, which seems to be sleepy, reducing the appetite and weight of a small rat and a small pork without causing Nauuseea or other digestive symptoms. More studies must be studied to check the safety and effectiveness of molecules in people. But this discovery gives a talisman sample in the future of obesity treatment.
Semaglutide emergency and similar drugs in the past few years of bones True revolution For obesity medical fields These drugs are also used for type 2 diabetes, proven to be more effective in helping people lose weight more than food and exercise only. 15% to 20% Lose weight in the SEMAGLUTIDE clinical experiment by imitation of GLP-1, which is a hormone that helps control our appetite and metabolism in other functions (some drugs such as Tirzepatide, mimic both GLP-1 and other related hormones).
It is well known that these drugs are often known, causing annoying GI and may cause more successful complications such as Gastroparesis (Paralysis in the stomach) Scientists also work to find and develop new drugs that can lose more weight or offer other facilities such as use as a drug. In the veins, Stanford medical researchers have invented new strategies to search for their drug applicants.
Many hormones in the body will be activated only when the substance is separated from the specific enzymes. These initial substances are called prohormones and the enzyme family. It is called Prohormone Convertases. The researchers look at one of these enzymes. Prohormone Convertase 1/3, which is well known to help produce GLP-1. To increase the speed in this discovery process, they have developed a computer algorithm. (Nickname Peptide with nickname) to limit molecules that may occur suitable for their criteria.
This screening found the initial set of 373 Prohormones that can give 2,700 different peptides (Peptides are usually the creation of large proteins. But they can have their own outstanding functions in the body). From there, the researchers tested the 100 peptides they knew? Sisters Paste May affect the hunger of the brain (including the GLP-1 for comparison) and finally, they specify one molecule that seems to have a special peptides with 12 amino acids called peptides related to Brinp2 or BRP.
After that, scientists tested the BRP on the laboratories and small pigs (Minipigs think it is similar to people closely. In metabolism– They found that BRP only once reduced the appetite of both animals in the short -term, sometimes up to 50% and a rat with obesity because the BRP has a significant weight loss from the team two weeks, with most of the weight being stored.
Additional experiments show that the impact of BRP's hunger reduction in the brain is not related to the GLP-1 receiver and it does not cause the animal to experience the GI related to the Ozopic. An animal that uses do not change in the movement of anxiety behavior or water consumption that BRP can accept when used as a drug.
“The receiver specified by Semaglutide can be found in the brain but still in the intestines, the hole and other tissues. That is why Ozer SIM has a wide impact, including slowing down the food movement through the gastrointestinal tract and reducing blood sugar levels.” statement From university “On the other hand, BRP seems to be only in Hypothalamus, which controls appetite and metabolism.”
Of course, the discovery of the team is a preliminary matter now. It will take more time and research, including clinical experiments that are successful in the beginning of humans before BRP should be seen as a great thing in the treatment of obesity. But the findings of the team are the latest things that suggest that Semaglutide has sparked the truly seafood changes in the treatment of obesity. There are currently dozens of experimental drugs in the pipe that threatens to be competitors or even too much. OZEmpic/Wegovy including Different formulas Or Semaglutide for their part. Svensson and her colleagues have already submitted a patent about BRP and she has established a company that she hoped to develop clinical molecules.
There is no drug without side effects. But the future of obesity may be much less involved with Nauuseea.