England winger Immanuel Feyi-Waboso will miss the entire Six Nations after dislocating his shoulder sustained on club duty in Exeter last month.
Feyi-Waboso will undergo surgery on the wrist he injured against Sale on December 21, which will rule him out for around three months, the PA news agency has learned.
The 22-year-old is one of England's most dangerous players with a strike rate of five tries in eight matches and, if fit, would be automatic selection for the Six Nations opener against Ireland on February 1.
Apart from the failure of Steve Borthwick's hopes of overseeing a revival in the Championship after a poor autumn, Feyi-Waboso has been denied the most important stage of all to claim British and Irish Lions selection.
Andy Farrell leads the Lions to Australia this summer and the Chiefs finisher was favorite for one of the back three spots due to his impact since his Test debut in last year's Six Nations.
He was also forced to sit out the games against South Africa and Japan in November after suffering concussion against Australia.
Feyi-Waboso impressed during England's indifferent Autumn Nations Series campaign
His absence stretches England's back-three resources with George Furbank likely to miss the start of the Championship with a broken arm.
Ollie Sleightholme and Tom Roebuck will compete to fill the vacant wing, although the former limped off in Northampton's win over Bath on Sunday.
Borthwick has named his Six Nations squad next Tuesday, with the head coach set to turn around England's fortunes as his position after a disappointing 2024 is scrutinised.
Sky Sports+ has officially launched and will be integrated into it Sky TVstreaming service NOW and The Sky Sports appgiving Sky Sports customers access to over 50 per cent more live sport this year at no extra cost. Learn more here.