Premier League Predictions: Gameweek 22

The 2025 Premier League midweek opener certainly did not disappoint.

Before Amadchester United struck late on down Southampton after falling behindLiverpool's slip at Nottingham Forest was captured by Arsenal in the North London Derby. The Reds' lead at the summit is now just four points, with momentum set to shift in favor of the Gunners.

Mikel Arteta's side, however, must mount a breakaway. It was this time last year when Arsenal came to their senses to push Manchester City all the way, and it may take something similar to claim a maiden title in more than 20 years, in May.

Saturday feels significant with the two title favorites in action against tricky opposition.

Here's how 90 min weekend projects Premier League action to disclose

Before we get knee deep into the narratives of the title race, the heat Newcastle are again involved in the early start, as they welcome a similar bloom Bournemouth in St. James' Park.

The Cherries are without a striker and set for a fight until Evanilson returns, but they came ever closer to securing three points at Stamford Bridge on Tuesday. Andoni Iraola's coaching will no doubt help Saturday's visitors in a difficult environment, but slowing down the Magpies on home soil has proved a futile task for so many in recent weeks.

Eddie Howe's men are up to fourth after securing their sixth Premier League win on the bounce against Wolves on Wednesday.

After a flat opening 45 minutes, Liverpool turned it on in the second half against Nottingham Forest last time out but were only able to collect one point. It's a result Arne Slot may have taken before kick-off, although his side have shown previously unseen weaknesses over the past month.

They can't let their little clash happen on Saturday when they get one Brentford the team that came back from two goals down to draw with Manchester City in midweek. The Bees rank among the most prolific and prolific home players in the Premier League this season. Another one Liverpool slide will aim to be caught by Arsenalwho face Aston Villa at the beginning of the evening.

Villa completed the double against Mikel Arteta's side last season, dashing their title hopes, but the Gunners won the reverse fixture 2-0 in August.

In other matches of the day, Leicesterwho have lost their last five league games welcome mid-table Fulham at the King Power Stadium, while Graham Potter's West Ham expect a resurrected one Crystal Palace in an all London affair.

Tottenham will still be without an endless list of players when they face off Everton at Goodison Park, but Ange Postecoglou can't afford to wait until February (when Spurs need to be healthier) to start picking up points.

Their work in the cup has certainly kept the Greco-Australian boss in the job, with Spurs picking up just five points from a possible 27 going into Sunday's game. They struggle against deep defenses and Everton will prove a difficult task given their threat from established performances. David Moyes suffered defeat on his return to Goodison against Villa on Wednesday.

It appeared as if Man Utd would endure a humiliating home defeat to bottom-of-the-table Southampton on Thursday, with a dismal first-half performance capped by Manuel Ugarte's own goal. Then Amad happened.

As a result, the Theater of Dreams awaits of Brighton visit The Seagulls have enjoyed success at Old Trafford in the recent past and they go into the game having secured their first win since November at Ipswich.

Southampton have offered competence with Ivan Juric at the helm, but they have another scary day away on Sunday with Nottingham Forest welcoming them to the City Ground.

After putting in a spirited performance in the defeat to Brighton, Ipswich welcome Manchester City on Portman Street. City are starting to click in attack but they remain noticeably vulnerable in defence. Erling Haaland will be eager to celebrate his new deal by one or three goals in East Anglia.

Gameweek 22 concludes at Stamford Bridge on Monday night with the extra-time fixtures Chelsea taking over threatened with decline Wolves.

Enzo Maresca's Blues have hit a wall but Cole Palmer remains extremely good at the sport. They always have a chance, especially if they have the talisman proves his ability to start.

The new Wolves manager's bounce has worn off rather quickly after a bright start to Vitor Pereira's reign and the Portuguese manager will have to smooth over a mistake over the coming weeks. There is no room for rest, but Chelsea's current plight should give them a sniff.

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